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KMID : 0613820110210030435
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Journal of Life Science
2011 Volume.21 No. 3 p.435 ~ p.443
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Effect of Treadmill Exercise Training on the Expression of PGC-1α, GLUT-1, Tfam Proteins and Antioxydent Ezymes in Brain of STZ-Induced Diabetic Rats
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Park Noh-Hwan
Lee Jin
Jung Kuk-Hyun
Choi Bong-Am
Jang Hyung-Chae
Lee Suk-In
Lee Dong-Soo
Cho Joon-Yong
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Abstract
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The purpose of this study is to identify the effects of exercise training [ET, 10~18 m/min (speed), 20~30 min (exercise duration)/a day for 5 day/wk, 6 wk) on PGC-1α, GLUT-1, Tfam, Cu,Zn-SOD and Mn-SOD proteins in brain of STZ-induced diabetic rats. The male Sprague-Dawley (SD) rats were single-injected intraperitoneally with 50㎎/㎏ of streptozotocin (STZ) to produce STZ-induced diabetic rats. Rats were divided into 3 experimental groups with 8 rats in each group, as follows: (1) non-STZ group (n=8), (2) STZ-CON group (n=8), (3) STZ-EXE group (n=8). The results of this study suggest that i) serum glucose level was significantly reduced in STZ-EXE group compared with STZ-CON group (p＜0.05), ii) PGC-1α (p＜0.001), mtPGC-1α (p＜0.001), GLUT-1 (p＜0.001), and mtTfam (p＜0.001) proteins in brain of STZ-induced diabetic rats were significantly increased in STZ-EXE group compared with STZ-CON group, iii) Cu,Zn-SOD (p＜0.001) and Mn-SOD (p＜0.01) proteins in the STZ-induced diabetic rats were significantly increased in STZ-EXE group compared with STZ-CON group. In conclusion, the findings of the present study reveal that treadmill exercise training increases brain GLUT-1 protein level possibly through up-regulation of PGC-1α and Tfam proteins which represent key regulatory components of stimulation of brain mitochondrial biogenesis. In addition, treadmill exercise training may prevent oxidative stress by up-regulation of Cu,Zn-SOD and Mn-SOD proteins in the STZ-induced diabetic rats.
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KEYWORD
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Treadmill exercise training, STZ-induced diabetic rat, PGC-1α, GLUT-1, Tfam, Cu, Zn-SOD, Mn-SOD
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